Background: Obesity is associated with pain, reduction of function and quality of life in patients with osteoarthritis (OA). Aim: To describe the clinical profile of women with knee OA according to their body mass index (BMI). Material and Methods: Observational study in 308 women with knee OA. According to their BMI, they were classified as normal-weight, overweight and obese. The primary outcome measure was functionality evaluated with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcomes were sleep quality evaluated using the Pittsburgh Sleep Quality Index (PSQI) and quality of life assessed with the European Quality of Life Five Dimension (EuroQol-5D). Results: WOMAC, PSQI and EuroQol-5D scores were significantly higher in obese women. Conclusions: Overweight and obese women with OA have more sleep disorders, reduction on functionality and quality of life compared to their normal weight counterparts.

Os objetivos deste estudo foram caracterizar e esclarecer as relações entre os vários domínios cognitivos afetados em pacientes com DPOC e a doença em si, assim como determinar a prevalência de comprometimentos cognitivos em tais pacientes. Para tanto, foi realizada uma revisão sistemática utilizando as seguintes bases de dados: PubMed, Scopus e ScienceDirect. Os artigos incluídos forneciam informações sobre os comprometimentos cognitivos em pacientes com DPOC. A revisão dos achados de tais artigos mostrou uma relação significativa entre DPOC e comprometimento cognitivo. Os domínios cognitivos mais estudados são a memória e a atenção. Memória verbal e aprendizagem constituem o segundo domínio cognitivo mais comumente prejudicado em pacientes com DPOC. A prevalência de comprometimento da memória visuoespacial e da memória visual intermediária é 26,9% e 19.2%, respectivamente. Observamos que o comprometimento cognitivo está associado ao perfil de gravidade da DPOC e suas comorbidades. A revisão dos artigos demonstrou que há um comprometimento considerável dos domínios memória e atenção em pacientes com DPOC. Investigações futuras devem abordar os comprometimentos em diferentes domínios cognitivos em conformidade com o estágio da doença em pacientes com DPOC.

The objectives of this study were to characterize and clarify the relationships between the various cognitive domains affected in COPD patients and the disease itself, as well as to determine the prevalence of impairment in the various cognitive domains in such patients. To that end, we performed a systematic review using the following databases: PubMed, Scopus, and ScienceDirect. We included articles that provided information on cognitive impairment in COPD patients. The review of the findings of the articles showed a significant relationship between COPD and cognitive impairment. The most widely studied cognitive domains are memory and attention. Verbal memory and learning constitute the second most commonly impaired cognitive domain in patients with COPD. The prevalence of impairment in visuospatial memory and intermediate visual memory is 26.9% and 19.2%, respectively. We found that cognitive impairment is associated with the profile of COPD severity and its comorbidities. The articles reviewed demonstrated that there is considerable impairment of the cognitive domains memory and attention in patients with COPD. Future studies should address impairments in different cognitive domains according to the disease stage in patients with COPD.

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease with a prevalence that increases with the aging of the subject. It presents a high prevalence of comorbidities, such as cognitive decline, which is gaining great clinical relevance in recent years. Factors such as pulmonary function, hypoxemia, hypercapnia or exacerbations contribute to the decline of cognitive functions. The nutritional status has been added to these factors as contributing to cognitive function decline when presenting in COPD. Objective: To evidence the relationship between cognitive decline, nutritional status and the clinical profile of patients admitted because of an acute exacerbation of COPD (AECOPD). Methods: 110 subjects hospitalized because of COPD, divided in two groups according to their nutritional status and assessment of cognitive decline at admittance, nutritional status and clinical profile. Results: Significant differences between groups concerning nutritional status in anthropometric variables (sex and IMC), functional ability (Barthel index and Daily Life Activities Scale), quality of life (Euroqol- 5D y SGRQ), sleep quality (Pittsburgh), mood (HAD) and cognitive decline (MoCa attention, MoCa abstraction). (p<0.05). Conclusion: Cognitive function is affected in COPD patients with an altered nutritional status when compared to those with a normal nutritional status. The nutritional decline is a factor contributing to the impairment of cognitive functions in this kind of patients, particularly a decline in attention and abstraction ability.

Introducción: La enfermedad pulmonar obstructiva crónica (EPOC) es una enfermedad progresiva, cuya prevalencia aumenta con la edad. Se caracteriza por su elevado número de comorbilidades, entre ellas el deterioro cognitivo, que ha ido adquiriendo gran relevancia clínica en los últimos años. Factores como la función pulmonar, la hipoxemia, la hipercapnia o las exacerbaciones contribuyen al deterioro de las funciones cognitivas. Se ha incluido el estado nutricional como un factor más que presentándose en la EPOC, contribuya también al deterioro de la funciones cognitivas. Objetivo: Evidenciar la relación entre el deterioro cognitivo, el estado nutricional y el perfil clínico de los pacientes que ingresan por exacerbación aguda de EPOC (EAEPOC). Metodología: Ciento diez sujetos hospitalizados por EAEPOC, divididos en dos grupos según su estado nutricional y evaluación a su ingreso de deterioro cognitivo, estado nutricional y perfil clínico. Resultados: Diferencias significativas entre grupos de estado nutricional en las variables antropométricas (sexo e IMC), capacidad funcional (Índice de Barthel y escala de Actividades de la Vida Diaria) calidad de vida (Eurool-5D y SGRQ), calidad de sueño (Pittsburgh), estado de ánimo (HAD) y deterioro cognitivo (MoCa atención, MoCa abstracción). (p<0.05). Conclusión: Las funciones cognitivas se ven afectadas en pacientes EPOC con un estado nutricional alterado, en comparación con aquellos con un estado nutricional normal. El deterioro nutricional es un factor que contribuye al deterioro de las funciones cognitivas en este tipo de pacientes; en concreto al deterioro de la atención y la capacidad de abstracción.